Complete list of very incumbent Senator to lose in 1st Midterm of President of opposing Party

Only 22 Senators ever lost their re-election during the first midterm of a President from the opposing party. The only three Presidents to successfully pick up seats and convince voters in more than one state that they picked the wrong Senator six years earlier were Franklin D. Roosevelt (defeated 7 Republican incumbents in 1934), Donald Trump (4 in 2018) and John F. Kennedy (2 in 1962).

The following is the list of the Presidents and their success or failure in defeating Senators from the opposing party in their first Mid-term. This does NOT include a few cases of Senators who were appointed or first-time nominees so had NOT won an election six years previous.

• 2018 - Donald Trump (Republican) defeated 4 Senators from opposing Party who won an election 6 years earlier while gaining 1 to 2 seats total for his party pending the West Virginia runoff. These wins by state included; 1, Indiana, Mike Braun beat Joe Donnelly, first elected in 2012; 2, Missouri, Josh Hawley d. Claire McCaskill, first elected in 2006; 3, North Dakota, Kevin Cramer d. Heidi Heitkamp, first elected in 2006; and 4, Florida, Ric Scott d. Bill Nelson 1st elected 2000.
• 2010 - Barack Obama (Democrat) lost seats and failed to defeat any opposing incumbent.
• 2002 - George W. Bush (Republican) Defeated 1 Senator from opposing Party who won an election 6 years earlier while gaining 1 seat total for his party. The one win was in Georgia, Saxby Chambliss d. Max Cleland, first elected in 1996.
• 1994 - Bill Clinton (Democrat) lost seats and failed to defeat any opposing incumbent
• 1990 - George H. W. Bush (Republican) lost seats and failed to defeat any opposing incumbent
• 1982 - Ronald Reagan (Republican) Defeated 1 Senator from opposing Party who won an election 6 years earlier, while not gaining 1 seat for his party. The one win was in Nevada, Chic Hect beat Howard Cannon, 1st elected in 1958.
• 1978 - Jimmy Carter (Democrat) defeated 2 Senators from opposing Party who won an election 6 years earlier BUT losing several seats for a net 2-seat loss for his party. These wins by state included; 1, Massachusetts, Paul Tsongas d. Edward Brook, first elected in 1966; 2, Michigan, Carl Levin d. Robert Giffin, first elected in 1966.
• 1974 - Gerald Ford (Republican) lost seats and failed to defeat any opposing incumbent.
• 1970 - Richard Nixon (Republican) Defeated 1 Senator from opposing Party who won an election 6 years earlier while gaining  2 seats total for his party. The one win was in Maryland, John Glenn Beall d. Joseph Tydings, first elected 1964.
• 1966 - Lyndon B. Johnson (Democrat) lost seats and failed to defeat any opposing incumbent.
• 1962 - John F. Kennedy (Democrat) defeated 2 Senators from opposing Party who won an election 6 years earlier while gaining 4 seats total for his party. These wins by state included; 1, Indiana, Birch Bayh d. Homer Capehart, first elected 1944; 2, Wisconsin, Gaylord Nelson d. Alexander Wiley, first elected in 1938.
• 1954 - Dwight D. Eisenhower (Republican) Defeated 1 Senator from opposing Party who won an election 6 years earlier while losing 2 seats total for his party. The one win was in  Iowa, Thomas Martin d. Guy Gillette, first 1st elected in 1936 special and then 1938 for full-term.
• 1946 - Harry S. Truman (Democrat) lost seats and failed to defeat any opposing incumbent.
• 1934 - Franklin D. Roosevelt (Democrat) defeated 7 Senators from opposing Party who won an election 6 years earlier, while gaining 9 seats total for his party. These wins by state included; 1, Connecticut, Francis Maloney d. Frederic Walcott, first elected in 1928; 2, Indiana, Sherman Minton d. Arthur Raymond Robinson, first elected in 1926 special then 1928 regular; 3, New Jersey, Harry Moore d. Hamilton Kean, first elected 1928; 4, Ohio, Vic Donahey d. Simeon Fess, first elected 1922; 5, Pennsylvania, Joseph Guffey d. David Reed, first elected 1922; 6, Rhode Island, Peter Gerry d. Felix Hebert, first elected 1928;  7, West Virginia, Rush Holt d. Henry Hatfield. first elected 1928.
• 1930 - Herbert Hoover (Republican) Defeated 1 Senator from opposing Party who won an election 6 years earlier, while losing 6 seats total for his party. The one win was in  Iowa, Lester Dickinson d. Daniel Steck, first elected 1924 though the election was disputed for two years due to late arriving counts from rural counties, and he was not seated until the full US Senate settled the dispute and seated him in 1926.
• 1926 - Calvin Coolidge (Republican) lost seats and failed to defeat any opposing incumbent.
• 1922 - Warren G. Harding (Republican) defeated 2 Senators from opposing Party who won an election 6 years earlier while losing 7 seats total for his party. These wins by state included; 1, Nebraska, Robert Howell d. Gilbert Hitchcock, first elected 1911 as Nebraska allowed direct election even before 17th Amendment allowed first Direct elections in 1914; 2, Ohio, Simeon Fess d. Atlee Pomerene, who was also first elected in 1911. Since the first direct election of Senators occurred in most states in 1914, the first year that Senators stood for a second election during a new President’s mid-term was 1922. Before 1913 almost all State Legislators selected their US Senators.